This textbook on collaborative research in bioinformatics and systems biology, which are key elements of modern biology and health research, highlights and provides access to many of the methods, environments, results and resources involved, including integral laboratory data generation and experimentation and clinical activities. Collaborative projects embody a research paradigm that connects many of the top scientists, institutions, their resources and research across Europe and the world, resulting in world-class contributions to bioinformatics and systems biology.